General
Preferred name
Akt inhibitor IV
Synonyms
(E)-Akt inhibitor-IV ()
(E)-AKTIV ()
P&D ID
PD052099
CAS
959841-49-7
681281-88-9
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION This is compound 5233705 in (this is its ChemBridge reference). It was originally reported to be an AKT (protein kinase B) inhibitor . However, the primary molecular target(s) of this compound have not been clearly identified, and its action may involve activation of the PDK1 kinase upstream of AKT, modulation of mTORC2 or targets outside of the PI3-kinase/AKT pathway .
PI3-kinase/AKT pathway inhibitors are under investigation as anticancer and antiviral agents. (GtoPdb)
DESCRIPTION Selective ARF6 inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Akt inhibitor IV is an inhibitor of Akt activation that inhibits Akt-mediated nuclear export of Forkhead box class O transcription factor 1a (FOXO1a; IC50 = 625 nM) and reduces phosphorylation of Akt at Ser473 and Thr308 in a dose-dependent manner. (BOC Sciences Bioactive Compounds)
Cell lines
6
Organisms
4
Compound Sets
6
BOC Sciences Bioactive Compounds
5-2-benzothiazolyl-3-ethyl-2-methy-cas-681281-88-9-item-298490
Cayman Chemical Bioactives
15569
Guide to Pharmacology
5919
MedChem Express Bioactive Compound Library
HY-14971
Selleckchem Bioactive Compound Library
-e--akt-inhibitor-iv
Tocris Bioactive Compound Library
5985
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
487.2
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
6
Aromatic Ring Count
6
cLogP
7.32
TPSA
24.94
Fraction CSP3
0.1
Chiral centers
0.0
Largest ring
6.0
QED
0.23
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Akt (Protein Kinase B)
Pathway
PI3K/Akt/mTOR
Target
Akt
Akt,PI3K
Source data