General
Preferred name
Metenkefalin
Synonyms
MET-ENKEPHALIN ()
Methionine enkephalin ()
Tyr-Gly-Gly-Phe-Met-OH ()
[Met]enkephalin ()
Met-Enkephalin (trifluoroacetate salt) ()
P&D ID
PD051997
CAS
58569-55-4
Tags
drug candidate
natural product
biased GPCR ligand
available
Drug indication
Pain
Drug Status
investigational
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION MET-enkephalin (MENK) is an endogenous opioid peptide. It exhibits agonist activity at the δ- and μ-opioid receptors. MENK produces immunomodulatory, neuromodulatory, antinociceptive/analgesic, antidepressant, and gastrointestinal motility modulating activities. It has cytostatic activity vs. cancer cells and may help recruit NK cells to kill tumour cells . (GtoPdb)
Cell lines
0
Organisms
2
Compound Sets
8
BiasDB
Met-enk
Cayman Chemical Bioactives
23284
DrugBank
DB12668
DrugMAP
DMSZFTP
EU-OPENSCREEN Bioactive Compound Library
EOS100790
Guide to Pharmacology
1614
MedChem Express Bioactive Compound Library
HY-P0073
TargetMol Bioactive Compound Library
T7211
External IDs
37
Properties
(calculated by RDKit )
Molecular Weight
573.23
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
7
Rotatable Bonds
16
Ring Count
2
Aromatic Ring Count
2
cLogP
-0.46
TPSA
199.95
Fraction CSP3
0.37
Chiral centers
3.0
Largest ring
6.0
QED
0.14
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Neuroscience
Endocrinology/Hormones
GPCR/G protein
Neuronal Signaling
Target
Opioid Receptor
Source data