General
Preferred name
SUBSTANCE P
Synonyms
CHEMBL235363 ()
Neurokinin P ()
Substance P acetate (33507-63-0 Free base) ()
Neurokinin P acetate ()
Substance P (TFA) ()
Neurokinin P (TFA) ()
Substance P TFA ()
Substance P acetate ()
Substance P (trifluoroacetate salt) ()
[3H]SP (human, mouse, rat) ()
Neuropeptide sp-1 ()
Substance p (1-11) ()
Sh-oligopeptide-73 ()
P&D ID
PD051990
CAS
33507-63-0
11035-08-8
148470-19-3
Tags
available
probe
drug candidate
Drug indication
Discovery agent
Seasonal allergic rhinitis
Drug Status
investigational
Max Phase
1.0
Probe info
Probe type
P&D approved
calculated probe
Probe selectivity
protein-selective
Probe sources
Tool Compound Set
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
7
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).
DESCRIPTION
Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Substance P acetate is a peptide mainly secreted by neurons and is involved in many biological processes including nociception and inflammation. Substance P acetate is a neuroinflammatory factor that can act as a neurotransmitter and neuromodulator in the central nervous system and can be used to study cardiovascular and neurological diseases.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
3
Compound Sets
10
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugMAP
ReFrame library
Selleckchem Bioactive Compound Library
Tool Compound Set
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
34
Molecular Weight
1346.73
Hydrogen Bond Acceptors
17
Hydrogen Bond Donors
15
Rotatable Bonds
42
Ring Count
4
Aromatic Ring Count
2
cLogP
-3.71
TPSA
519.13
Fraction CSP3
0.59
Chiral centers
10.0
Largest ring
6.0
QED
0.02
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Neurokinin 1 receptor
Endogenous Metabolite
Human Endogenous Metabolite
Neurokinin Receptor
NK1
TACR1, TACR2, TACR3
MOA
neurokinin receptor antagonist
Pathway
GPCR/G protein
Metabolism
Neuroscience
Metabolic Enzyme/Protease
Neuronal Signaling
Source data
