General
Preferred name
AMMONIUM CHLORIDE
Synonyms
Ammonium chloride, AR, 99.5% ()
E-510 ()
E510 ()
Darammon ()
Chlorammonic ()
Ins no.510 ()
Ins-510 ()
Amoklor ()
FEMA NO. 4494 ()
Ammonium muriaticum ()
ammonium muriate ()
Salammoniacus ()
Sal ammoniac ()
Catalyst rd ()
Ammonium chloride ((nh4)cl) ()
E 510 ()
Tussi Ammon Co ()
P&D ID
PD051967
CAS
12125-02-9
Tags
available
inorganic
drug
Drug Status
investigational
approved
vet_approved
Max Phase
Phase 4
Drug indication
Acidifier
Diuretic
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA Ammonium chloride increases acidity by increasing the amount of hydrogen ion concentrations.; ; Ammonium chloride can be used as an expectorant due to its irritative action on the bronchial mucosa. This effect causes the production of respiratory tract fluid which in order facilitates the effective cough.
TOXICITY LD50 "Rat" after oral administration is: 1650 mg/kg.; Overdosage of Ammonium Chloride has resulted in a serious degree of metabolic acidosis, disorientation, confusion and coma. If metabolic acidosis occur following overdosage, the administration of an alkalinizing solution such as sodium bicarbonate or sodium lactate will serve to correct the acidosis.; ; Patients administering Ammonium chloride should be watched to the signs of ammonia toxicity including (pallor, sweating, irregular breathing, bradycardia, cardiac arrhythmias, local and general twitching, tonic convulsions and coma).; It should be used with caution in patients with high total CO2 and buffer base secondary to primary respiratory acidosis.; Intravenous administration should be slow to avoid local irritation and toxic effects.;
METABOLISM Ammonium ion is converted to urea in the liver; chloride ion replaces bicarbonate.;
INDICATION 1. Expectorant in cough syrups.; 2. The ammonium ion (NH4+) in the body plays an important role in the maintenance of acid-base balance. The kidney uses ammonium (NH4+) in place of sodium (Na+) to combine with fixed anions in maintaining acid-base balance, especially as a homeostatic compensatory mechanism in metabolic acidosis.; The therapeutic effects of Ammonium Chloride depend upon the ability of the kidney to utilize ammonia in the excretion of an excess of fixed anions and the conversion of ammonia to urea by the liver, thereby liberating hydrogen (H+) and chloride (Cl–) ions into the extracellular fluid.; Ammonium Chloride Injection, USP, after dilution in isotonic sodium chloride injection, may be indicated in the treatment of patients with:; (1) hypochloremic states and (2) metabolic alkalosis.
Compound Sets
5
ChEMBL Approved Drugs
CHEMBL1200939
ChEMBL Drugs
CHEMBL1200939
DrugBank
DB06767
DrugBank Approved Drugs
DB06767
MedChem Express Bioactive Compound Library
HY-Y1269
External IDs
30
Properties
(calculated by RDKit )
Molecular Weight
53.0
Hydrogen Bond Acceptors
0
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
-2.62
TPSA
36.5
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
0.0
QED
0.31
QED
0.31
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Autophagy
Source data