General
Preferred name
DIPRAGLURANT
Synonyms
ADX48621 ()
ADX-48621 ()
P&D ID
PD051953
CAS
872363-17-2
Tags
available
drug candidate
Drug indication
Mood disorder
Dyskinesia
Parkinson disease
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Dipraglurant (ADX48621) is a potent, selective, orally active and brain penetrant mGluR5 negative allosteric modulator (NAM), with an IC50 of 21 nM. Dipraglurant can reduce Levodopa-induced dyskinesia (LID) in vivo[1][2]. Dipraglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
PRICE 245
DESCRIPTION Dipraglurant is a mGlu5 receptor negative allosteric modulator. It is currently in phase II for the treatment of dyskinesia in Parkinson's disease. (BOC Sciences Bioactive Compounds)
DESCRIPTION Dipraglurant (ADX48621) is a negative alteration modulator (NAM) of mGluR5 that inhibits dyskinesia in the LID macaque model. (TargetMol Bioactive Compound Library)
Compound Sets
11
BOC Sciences Bioactive Compounds
dipraglurant-cas-872363-17-2-item-84-453459
Cayman Chemical Bioactives
42535
ChEMBL Drugs
CHEMBL2346738
Drug Repurposing Hub
DrugBank
DB12733
DrugMAP
DM6GTMD
Guide to Pharmacology
6452
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL2346738
MedChem Express Bioactive Compound Library
HY-14859
ReFrame library
TargetMol Bioactive Compound Library
T15134
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
265.1
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
3
cLogP
2.85
TPSA
30.19
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
mGluR5
GRM5
mGluR
MOA
glutamate receptor negative allosteric modulator
Pathway
Neuroscience
GPCR/G protein
Neuronal Signaling
Source data