General
Preferred name
SB-243213
Synonyms
SB 243213 dihydrochloride ()
SB 243213 (hydrochloride) ()
SB 243213 ()
SB-243213 (hydrochloride) ()
P&D ID
PD051919
CAS
200940-22-3
200940-23-4
1780372-25-9
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Selective 5-HT2C inverse agonist
(Tocriscreen Plus)
DESCRIPTION
SB 243213 dihydrochloride is a 5-HT2C inverse agonist (pKb = 9.8) with selectivity over other 5-HT2 subtypes (pKi = 6.8, 7.0 and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C, respectively). SB 243213 exhibits >100-fold selectivity over 50 other receptors, ion channels and enzymes. SB 243213 shows anxiolytic activity in rat models.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
DrugMAP
DrugMatrix
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Other bioactive compounds
ReFrame library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
36
Molecular Weight
428.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
3
cLogP
5.5
TPSA
67.35
Fraction CSP3
0.23
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Target
5-HT Receptor
HTR2A, HTR2B, HTR2C, HTR6
Pathway
Neuronal Signaling
GPCR/G protein
MOA
serotonin receptor inverse agonist
Source data
