General
Preferred name
BMY-7378
Synonyms
BMY 7378 dihydrochloride ()
BMY7378 HCl ()
BMY-7378 dihydrochloride ()
BMY 7378 ()
BMY 7378 ()
P&D ID
PD051724
CAS
21102-95-4
21102-94-3
1348935-37-4
Tags
available
drug candidate
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
BMY 7378 is a selective antagonist of ¦Á1D-adrenoceptor (¦Á1D-AR). BMY 7378 binds to membranes expressing the cloned rat ¦Á1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat ¦Á1A-AR (Ki=800 nM) or the hamster ¦Á1B-AR (Ki=600 nM). BMY 7378 is a 5-HT1A receptor partial agonist[1][2].
PRICE
33
DESCRIPTION
BMY 7378 dihydrochloride (BMY7378 HCl) , ??1D-adrenergic receptor antagonist, is a weak partial agonist/antagonist of 5-HT1A receptor.
DESCRIPTION
Potent CCK2 antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Partial 5-HT1A serotonin receptor agonist; alpha1D adrenoceptor antagonist
(LOPAC library)
DESCRIPTION
Selective α1D antagonist
(Tocriscreen Total)
DESCRIPTION
BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
BMY 7378 dihydrochloride (BMY7378 HCl) , α1D-adrenergic receptor antagonist, is a weak partial agonist/antagonist of 5-HT1A receptor.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
19
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
DrugMatrix
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
385.24
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
1
cLogP
2.53
TPSA
53.09
Fraction CSP3
0.64
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
5-HT1A
Target
5-HT1C
D2
α1D-adrenoceptor
α2C-adrenoceptor
ADRA1A, ADRA1B, ADRA1D, HTR1A
5-HT Receptor,Adrenergic Receptor
5-HT Receptor
Adrenergic Receptor
Primary Target
Adrenergic ?1 Receptors
MOA
Antagonist
5-HT1A Receptor Antagonists
alpha1D-Adrenoceptor Antagonists
adrenergic receptor antagonist, serotonin receptor antagonist
Member status
member
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Solubility
Soluble in water (5 mg/ml), DMSO (92 mg/ml), and ethanol (20 mg/ml)
Source data
