General
Preferred name
BMY-7378
Synonyms
BMY 7378 dihydrochloride ()
BMY7378 HCl ()
BMY-7378 dihydrochloride ()
BMY 7378 ()
BMY 7378 ()
P&D ID
PD051724
CAS
21102-95-4
21102-94-3
1348935-37-4
Tags
drug candidate
natural product
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Potent CCK2 antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Partial 5-HT1A serotonin receptor agonist; alpha1D adrenoceptor antagonist
(LOPAC library)
DESCRIPTION
Selective α1D antagonist
(Tocriscreen Total)
DESCRIPTION
BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
18
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
DrugMatrix
Guide to Pharmacology
LOPAC library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Molecular Weight
385.24
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
1
cLogP
2.53
TPSA
53.09
Fraction CSP3
0.64
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
5-HT1A
Pathway
GPCR/G protein
Neuroscience
Target
5-HT1C
??1D-adrenoceptor
??2C-adrenoceptor
D2
ADRA1A, ADRA1B, ADRA1D, HTR1A
5-HT Receptor,Adrenergic Receptor
Primary Target
Adrenergic ?1 Receptors
MOA
Antagonist
5-HT1A Receptor Antagonists
alpha1D-Adrenoceptor Antagonists
adrenergic receptor antagonist, serotonin receptor antagonist
Member status
member
Solubility
Soluble in water (5 mg/ml), DMSO (92 mg/ml), and ethanol (20 mg/ml)
Source data
