General
Preferred name
BRL-15572
Synonyms
BRL 15572 ()
BRL 15572 hydrochloride ()
BRL 15572 dihydrochloride ()
BRL 15573 dihydrochloride ()
BRL-15572 dihydrochloride ()
dihydrochloride ()
BRL15572 ()
BRL-15572 (dihydrochloride) ()
BRL-15,572 ()
P&D ID
PD051723
CAS
193611-72-2
734517-40-9
1173022-77-9
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
BRL-15572 is a selective antagonist of the serotonin 5-HT1D receptor.
(GtoPdb)
DESCRIPTION
BRL-15572 displays high affinity and selectivity for h5-HT1D receptors. BRL-15572 has 60-fold higher affinity for h5-HT1D than 5-HT1B receptors.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Potent and selective 5-HT1D serotonin receptor antagonist
(LOPAC library)
DESCRIPTION
Selective h5-HT1D antagonist
(Tocriscreen Total)
DESCRIPTION
BRL 15572 hydrochloride is a selective h5-HT1D antagonist with 60-fold selectivity over h5-HT1B.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
9
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
DrugMAP
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
406.18
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
4.66
TPSA
26.71
Fraction CSP3
0.28
Chiral centers
1.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Selectivity
5-HT1D
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
5-HT1A
5-HT2A
5-HT2B
5-HT7
5-HT Receptor
MOA
5-HT Receptor antagonist
Source data