General
Preferred name
Rec 15/2615
Synonyms
Rec 15/2615 dihydrochloride ()
REC2615 ()
Rec-15/2615 ()
Rec 15/2615 (hydrochloride) ()
P&D ID
PD051618
CAS
1782573-48-1
173059-17-1
Tags
available
drug candidate
Drug indication
Discovery agent
Female sexual arousal dysfunction
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 172
DESCRIPTION Rec 15/2615 dihydrochloride is an antagonist of ??1B-adrenergic receptor.
DESCRIPTION Potent and selective NK3 antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Selective alpha1B antagonist (Tocriscreen Plus)
DESCRIPTION Rec 15/2615 dihydrochloride is an antagonist of α1B-adrenergic receptor. (TargetMol Bioactive Compound Library)
DESCRIPTION Rec 15/2615 dihydrochloride is a selective α1B-adrenoceptor antagonist (Ki= 0.3, 1.9 and 2.6 nM at human α1B, α1A and α1D receptors respectively) potentially for the treatment of female sexual dysfunction. (BOC Sciences Bioactive Compounds)
Compound Sets
14
BOC Sciences Bioactive Compounds
rec-15-2615-dihydrochloride-cas-173059-17-1-item-129620
Cayman Chemical Bioactives
27677
Concise Guide to Pharmacology 2017/18
8459
Concise Guide to Pharmacology 2019/20
8459
Concise Guide to Pharmacology 2021/22
8459
Concise Guide to Pharmacology 2023/24
8459
Drug Repurposing Hub
DrugMAP
DM386JM
DMJ0FCG
EUbOPEN Chemogenomics Library
EUB0000981
Guide to Pharmacology
8459
ReFrame library
TargetMol Bioactive Compound Library
T23230
Tocris Bioactive Compound Library
3284
Tocriscreen Plus
3284
External IDs
25
Properties
(calculated by RDKit )
Molecular Weight
495.25
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
1
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
3
cLogP
3.09
TPSA
112.27
Fraction CSP3
0.42
Chiral centers
0.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Target
α1B-adrenergic receptor
ADRA1A
Primary Target
Adrenergic ?1 Receptors
MOA
Antagonist
Adrenergic Receptor antagonist
Pathway
GPCR/G protein
Neuroscience
Recommended Cell Concentration
10 nM
Source data