General
Preferred name
CX 614
Synonyms
CX-614 ()
CX614 ()
P&D ID
PD051552
CAS
191744-13-5
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION CX614 is a positive variant modulator of AMPA receptors that enhances excitatory postsynaptic potentials (amplitude and duration) by blocking and slowing the inactivation of responses to glutamate and automatically evokes excitatory postsynaptic currents in neuronal cultures. CX614 can be used in the study of psychiatric disorders such as depression[1][2].
PRICE 41
DESCRIPTION CX614 is a positive allosteric modulator of the AMPA receptor with respect to AMPA. (GtoPdb)
DESCRIPTION CX 614 has been found to be an AMPA modulator and has also been found to be an ampakine drug facilitating activation of glutamatergic AMPA receptors. (BOC Sciences Bioactive Compounds)
DESCRIPTION CX614 is a positive allosteric modulator of the AMPA receptor concerning AMPA. (TargetMol Bioactive Compound Library)
DESCRIPTION Selective TRPA1 activator (Tocris Bioactive Compound Library)
Compound Sets
5
BOC Sciences Bioactive Compounds
cx-614-cas-191744-13-5-item-55607
Guide to Pharmacology
7842
MedChem Express Bioactive Compound Library
HY-110175
TargetMol Bioactive Compound Library
T19698
Tocris Bioactive Compound Library
5149
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
247.08
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
1
cLogP
1.41
TPSA
48.0
Fraction CSP3
0.46
Chiral centers
1.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
AMPA
iGluR
Primary Target
AMPA Receptors
MOA
Modulator
Pathway
Neuroscience
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data