General
Preferred name
BPH-715
Synonyms
BPH715 ()
P&D ID
PD051516
CAS
1059677-23-4
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION BPH-715 is a bisphosphonate, inhibits Plasmodium liver-stage growth, with an IC50 of 10 ¦ÌM for Plasmodium exoerythrocytic forms in HepG2 cells[1].
PRICE 402
DESCRIPTION BPH-715 inhibits the liver-stage growth of P. falciparum with an IC50 of 10 ??M for P. falciparum exoerythrocytic forms in HepG2 cells.
DESCRIPTION BPH715 is a new generation of lipophilic bisphosphonates. It is potent in cell culture and effectively inhibited tumor cell growth and invasiveness. It is used as anticancer agents that block protein prenylation also have potent activity against Plasmodium liver stages. It has activity against a Plasmodium geranylgeranyl diphosphate synthase (GGPPS), as well as low nM activity against human farnesyl and geranylgeranyl diphosphate synthases. It is used to treat bone resorption diseases and has activity against a broad range of protists, including blood-stage Plasmodium spp. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
2
Compound Sets
4
BOC Sciences Bioactive Compounds
bph715-cas-1059677-23-4-item-475027
DrugMAP
DMTHW3F
Guide to Pharmacology
3196
MedChem Express Bioactive Compound Library
HY-118224
External IDs
12
Properties
(calculated by RDKit )
Molecular Weight
423.16
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
14
Ring Count
1
Aromatic Ring Count
1
cLogP
2.54
TPSA
131.0
Fraction CSP3
0.71
Chiral centers
2.0
Largest ring
6.0
QED
0.24
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Parasite
Pathway
Anti-infection
Solubility
10 mM in DMSO
Source data