General
Preferred name
IMMETHRIDINE
Synonyms
Immethridine dihydrobromide ()
Immethridine (hydrobromide) ()
P&D ID
PD051501
CAS
699020-93-4
87976-03-2
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
215
DESCRIPTION
Highly potent, mGlu1-selective non-competitive antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent H3 agonist, highly selective over H4
(Tocriscreen Total)
DESCRIPTION
Immethridine dihydrobromide is the dihydrobromide salt of immethridine, which is a highly selective, potent and novel histamine H3 receptor agonist with pEC50 value of 9.74. It shows 300-fold selectivity over the histamine H4 receptor and does not bind to H1 or H2 receptors at concentrations up to 10 μM.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Immethridine dihydrobromide is a novel, highly potent and selective histamine H3 receptor (H3R) agonist that inhibits dendritic cell function and alleviates experimental autoimmune encephalomyelitis.Immethridine dihydrobromide MesV induces depolarization of neurons and the MMN and prevents cardiorenal and renal injury. injury.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
Other bioactive compounds
ReFrame library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
32
Molecular Weight
159.08
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
1.4
TPSA
41.57
Fraction CSP3
0.11
Chiral centers
0.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Primary Target
Histamine H3 Receptors
MOA
Agonist
Histamine Receptor agonist
Target
HRH3
H3 agonist
H3 receptor
Source data
