General
Preferred name
alpha-methyl-5-HT
Synonyms
?-Methyl-5-hydroxytryptamine maleate ()
alpha-Methyl-5-hydroxytryptamine maleate ()
α-Methyl-5-hydroxytryptamine maleate ()
ALPHA-METHYL-5-HYDROXYTRYPTAMINE ()
5-HT,a-Me ()
?-methyl Serotonin (maleate) ()
α-methyl-5-HT ()
3-(2-Amino-propyl)-1H-indol-5-ol ()
.alpha.-methyl Serotonin (maleate) ()
P&D ID
PD051301
CAS
304-52-9
97469-12-0
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 5-HT2B agonist (Tocriscreen Plus)
DESCRIPTION 5-HT2 Serotonin receptor agonist (LOPAC library)
DESCRIPTION 5-HT2B agonist (Tocriscreen Total)
DESCRIPTION α-Methyl-5-hydroxytryptamine maleate, a salt of α-Methylserotonin maleate, is a 5-HT2B receptor selective agonist with pKi values of 8.4, 6.1 and 7.3 at 5-HT2B, 5-HT2A and 5-HT2C receptors respectively. It is used for forskolin-free cAMP assay for Gi-coupled receptors. (BOC Sciences Bioactive Compounds)
DESCRIPTION 3-(2-Amino-propyl)-1H-indol-5-ol is an antogonis of 5-hydroxytryptamine receptor. (Enamine Bioactive Compounds)
Compound Sets
10
BOC Sciences Bioactive Compounds
methyl-5-hydroxytryptamine-maleate-cas-97469-12-0-item-150297
Cayman Chemical Bioactives
28542
DrugMAP
DMCAYXF
DrugMatrix
Enamine Bioactive Compounds
EBC-06374
Guide to Pharmacology
152
Ki Database
5-HT,a-Me
LOPAC library
Tocriscreen Plus
0557
Tocriscreen Total
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
190.11
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
1.76
TPSA
62.04
Fraction CSP3
0.27
Chiral centers
1.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Selectivity
5-HT2
Source data