General
Preferred name
PBD-150
Synonyms
PBD150 ()
P&D ID
PD051247
CAS
790663-33-1
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PBD-150 is a human glutaminyl cyclase (hQC) Y115E-Y117E variant inhibitor, with a Ki value of 490 nM[1][2].
PRICE 69
DESCRIPTION PBD150 is a potent inhibitor of glutaminyl cyclase (QC), an enzyme which can modify the N-terminal glutamate residue of amyloid beta (Aβ) proteins to generate pyroglutamate-Aβ . (GtoPdb)
DESCRIPTION PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM) (TargetMol Bioactive Compound Library)
Compound Sets
6
Cayman Chemical Bioactives
36112
DrugMAP
DM1Y2F0
Guide to Pharmacology
8356
MedChem Express Bioactive Compound Library
HY-119173
Selleckchem Bioactive Compound Library
pbd-150
TargetMol Bioactive Compound Library
T7905
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
320.13
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
2
cLogP
2.28
TPSA
60.34
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.6
QED
0.6
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Amyloid-β
glutaminyl cyclase (hQC) Y115E-Y117E
Amyloid-¦Â
Beta Amyloid
Pathway
Neuronal Signaling
Neuroscience
Source data