General
Preferred name
L-873724
Synonyms
L873724 ()
P&D ID
PD051215
CAS
603139-12-4
Tags
available
probe
drug candidate
Drug indication
Asthma
Probe info
Probe type
calculated probe
Probe selectivity
protein-selective
Probe sources
Probe Miner (suitable probes)
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION L-873724 is a potent, orally bioavailable, selective and reversible[2] non-basic cathepsin K inhibitor, with IC50s of 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively[1]. L-873724 also exhibits an IC50 of 0.5 nM for rabbit cathepsin K. L-873724 inhibits bone resorption[2].
DESCRIPTION This compound is a specific cathepsin K inhibitor (compound 22 in the article), which is used as a functional probe in studying the effects of cathepsin K inhibition. (GtoPdb)
Cell lines
1
Organisms
0
Compound Sets
5
DrugMAP
DMUP516
Guide to Pharmacology
7860
MedChem Express Bioactive Compound Library
HY-50887
Probe Miner (suitable probes)
P43235/512408
ReFrame library
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
481.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
9
Ring Count
2
Aromatic Ring Count
2
cLogP
4.0
TPSA
99.06
Fraction CSP3
0.39
Chiral centers
2.0
Largest ring
6.0
QED
0.53
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Cathepsin
Pathway
Metabolic Enzyme/Protease
Source data