General
Preferred name
WS-3
Synonyms
Cyclohexanecarboxamide ()
N-Ethyl-p-menthane-3-carboxamide ()
N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide ()
WS 3 ()
TRPM8 agonist WS-3 ()
Framidice 3 ()
Ethyl menthane carboxamide, WS3, N-Ethyl-5-methyl-2-(1-methylethyl)-cyclohexanecarboxamide, Hexahydrobenzamide ()
TRPM8 antagonist WS-3 ()
P&D ID
PD051156
CAS
39711-79-0
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
TRPM8 agonist WS-3 is an agonist of TRPM8 with an EC50 of 3.7 ¦ÌM.
PRICE
29
DESCRIPTION
TRPM8 antagonist WS-3 (Cyclohexanecarboxamide) is an agonist of TRPM8( EC50 : 3.7 ??M).
DESCRIPTION
WS 3 is a cooling agent that acts as an agonist at TRPM8 receptors (EC50 = 3.7 μM).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
TRPM8 antagonist WS-3 (Cyclohexanecarboxamide) is an agonist of TRPM8( EC50 : 3.7 μM).
(TargetMol Bioactive Compound Library)
DESCRIPTION
Selective and non-competitive AMPA antagonist
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
7
BOC Sciences Bioactive Compounds
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
211.19
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
0
cLogP
2.83
TPSA
29.1
Fraction CSP3
0.92
Chiral centers
3.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
TRP Channel
TRPM8
Endogenous Metabolite
Primary Target
TRPM
MOA
Agonist
Pathway
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
Neuronal Signaling
Source data
