General
Preferred name
BAN-ORL-24
Synonyms
BAN ORL 24 ()
Banyu Compound-24 ()
BAN ORL 24 dihydrochloride ()
compound 24 [PMID: 16451050] ()
BAN ORL 24 (hydrochloride) ()
P&D ID
PD051081
CAS
1401463-54-4
475150-69-7
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
BAN ORL 24 is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) antagonist. BAN ORL 24 has antagonistic effect for nociceptin (NOP) receptor with KI value of 0.24 nM in CHO cell. BAN ORL 24 can be used for the research of cancer and analgesic[1].
PRICE
230
DESCRIPTION
BAN ORL 24 is a highly potent nociceptin/orphan FQ (N/OFQ) receptor (NOP) antagonist that can be used to study neurological diseases.
DESCRIPTION
compound 24 [PMID: 16451050] is a rationally designed NOP receptor antagonist .
(GtoPdb)
DESCRIPTION
Potent and selective NOP antagonist
(Tocriscreen Plus)
DESCRIPTION
Potent and selective NOP antagonist
(Tocriscreen Total)
DESCRIPTION
BAN ORL 24 dihydrochloride is a hydrochloride salt form of BAN ORL 24. BAN ORL 24, a spiro-isobenzofuran compound, has been found to be a NOP receptor antagonist and could be used to restrain the reduction of locomotor motions with brain permeability. IC50: 0.27 nM.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
BAN ORL 24, a spiro-isobenzofuran compound, has been found to be a NOP receptor antagonist and could be used to restrain the reduction of locomotor motions with brain permeability. IC50: 0.27 nM.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
JUMP-Target 1 Compound Set
MedChem Express Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Molecular Weight
433.27
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
2
cLogP
3.68
TPSA
44.81
Fraction CSP3
0.52
Chiral centers
1.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Opioid Receptor
OPRL1
Target Type
7-TM Receptors
MOA
nociceptin/orphanin FQ receptor antagonist
Pathway
GPCR/G protein
Neuronal Signaling
Source data
