General
Preferred name
BENZAMIDINE
Synonyms
BENZAMIDINE HYDROCHLORIDE ()
Benzamidine HCl ()
Benzamidine (hydrochloride) ()
Benzamidine (hydrochloride) ()
P&D ID
PD051080
CAS
1670-14-0
143504-23-8
206752-36-5
618-39-3
125772-71-6
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Benzamidine hydrochloride is a trypsin-like serine proteases with Kis of 20, 21, 97, 110, 320 and 750 ¦ÌM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively[1].
PRICE
29
DESCRIPTION
Benzamidine hydrochloride (Benzamidine HCl) is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 ??M, respectively).
DESCRIPTION
Benzamidine is a reversible competitive trypsin inhibitor with a Ki of 19 ¦ÌM[1]. Benzamidine shows inhibitory activity against homogeneous boar sperm acrosin with a Ki of 4 ¦ÌM[2].
DESCRIPTION
Peptidase inhibitor
(LOPAC library)
DESCRIPTION
Benzamidine is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Kis = 35, 350, and 220 µM, respectively). Benzamidine inhibits the autoactivation of human blood coagulation factor VII, useful as a tool for studying the interactions between this and other relevant growth factors.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Benzamidine hydrochloride (Benzamidine HCl) is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 μM, respectively).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
DrugBank
DrugMAP
Guide to Pharmacology
Ki Database
LOPAC library
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
62
Molecular Weight
120.07
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
0.97
TPSA
49.87
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.42
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Peptidase
Target
Ser/Thr Protease
Serine Protease
Serine/threonin kinase
Member status
virtual
Pathway
Metabolic Enzyme/Protease
Cell Cycle/Checkpoint
Metabolism
Proteases/Proteasome
Solubility
Soluble in water.
Source data
