General
Preferred name
cinaciguat
Synonyms
BAY 58-2667 ()
BAY 58-2667 hydrochloride ()
Cinaciguat (hydrochloride) ()
P&D ID
PD051027
CAS
646995-35-9
329773-35-5
Tags
available
drug candidate
Drug indication
Acute decompensated heart failure
Congestive heart failure
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Cinaciguat hydrochloride is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets.
DESCRIPTION
Cinaciguat is an activator of guanylate cyclase (sGC), and used for acute decompensated heart failure.
PRICE
154
DESCRIPTION
Potent and selective ALK2 and ALK3 inhibitor; promotes neural induction of hPSCs
(Tocris Bioactive Compound Library)
DESCRIPTION
An experimental drug as an an activator of sGC in an NO-independent manner (Kd = 3.2 nM).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Cinaciguat (BAY 58-2667) (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in Clinicalal development for acute decompensated heart failure.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Concise Guide to Pharmacology 2025/26
Drug Repurposing Hub
DrugBank
DrugMAP
Guide to Pharmacology
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
48
Molecular Weight
565.28
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
17
Ring Count
4
Aromatic Ring Count
4
cLogP
7.05
TPSA
87.07
Fraction CSP3
0.28
Chiral centers
0.0
Largest ring
6.0
QED
0.13
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Guanylate Cyclase
GUCY1A3, GUCY1B3
sGC activator
Primary Target
Guanylyl Cyclases
MOA
Activator
Soluble guanylate cyclase activator
Soluble Guanylyl Cyclase (sGC) Activators
Guanylate cyclase activator
Member status
member
Pathway
GPCR/G protein
Solubility
Soluble in DMSO
Source data
