General
Preferred name
GS-9667
Synonyms
CVT-3619 ()
CVT 3619 ()
GS 9667 ()
GS9667 ()
P&D ID
PD051022
CAS
618380-90-8
Tags
available
drug candidate
Drug indication
Hypertriglyceridemia
Drug Status
investigational
Max Phase
1.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
GS-9667 (CVT 3619), a novel N6-5'-substituted adenosine analog, is a selective, partial agonist of the A1 adenosine receptor (A1AdoR). GS-9667 binds to adipocyte membranes with high (KH=14 nM) and low (KL=5.4 ¦ÌM) affinities. GS-9667 reduces cyclic AMP content and release of nonesterified fatty acids from epididymal adipocytes with IC50 values of 6 nM and 44 nM, respectively. GS-9667 inhibits lipolysis and has the potential for Type 2 diabetes (T2DM) and dyslipidemia via lowering of free fatty acids (FFA)[1][2].
PRICE
227
DESCRIPTION
GS9667 is a new selective, partial agonist of the A(1) adenosine receptor (AR). It may be an effective therapy for Type 2 diabetes and dyslipidemia via lowering of free fatty acids (FFA). It was developed by Gilead and was in clinic phase 1 trials without progress.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
GS-9667, a selective and partial agonist of the A(1) adenosine receptor (AR), represents an effective therapy for Type 2 diabetes (T2DM) and dyslipidemia via lowering of free fatty acids (FFA).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
7
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
17
Molecular Weight
461.15
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
4
Rotatable Bonds
6
Ring Count
5
Aromatic Ring Count
3
cLogP
1.7
TPSA
125.55
Fraction CSP3
0.48
Chiral centers
6.0
Largest ring
6.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Target
Adenosine Receptor
Solubility
Soluble in DMSO
Source data
