General
Preferred name
OLANZAPINE
Synonyms
Olanzapine (LY170053) ()
P&D ID
PD051011
CAS
132539-06-1
Tags
natural product
drug
available
Drug Status
approved
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Olanzapine displays affinity for numerous receptors from the serotonin, histamine, alpha adrenergic, dopamine and muscarinic acetylcholine receptor families. Its antipsychotic properties are believed to arise from its antagonism of the dopamine D2 and 5-HT2A receptors.
Marketed formulations may contain olanzapine pamoate (PubChem CID 12085238). Olanzapine is represented on some databases with some of the double bonds in a different position. See CHEBI:7735 and CHEMBL715. (GtoPdb)
DESCRIPTION Olanzapine interacts with key receptors of interest in schizophrenia, having a nanomolar affinity for dopaminergic, serotonergic, alpha 1-adrenergic, and muscarinic receptors. (BOC Sciences Bioactive Compounds)
Compound Sets
8
AdooQ Bioactive Compound Library
A10667
BOC Sciences Bioactive Compounds
olanzapine-cas-132539-06-1-item-84-83215
Concise Guide to Pharmacology 2017/18
47
Concise Guide to Pharmacology 2019/20
47
Concise Guide to Pharmacology 2021/22
47
Concise Guide to Pharmacology 2023/24
47
Guide to Pharmacology
47
Ki Database
OLANZAPINE
External IDs
14
Properties
(calculated by RDKit )
Molecular Weight
312.14
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
2
cLogP
1.75
TPSA
30.87
Fraction CSP3
0.35
Chiral centers
0.0
Largest ring
7.0
QED
0.87
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Source data