General
Preferred name
SB-277011
Synonyms
SB-277011A ()
SB 277011A dihydrochloride ()
SB 277011A ()
SB-277011 (hydrochloride) ()
SB-277011A (hydrochloride) ()
SB 277011A (hydrochloride) ()
SB 277011-A ()
SB-277011 hydrochloride ()
P&D ID
PD050973
CAS
1226917-67-4
215803-78-4
215804-67-4
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 77
DESCRIPTION SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor (D3R) antagonist with Ki values of 10.7 nM and 11.2 nM at rodent and human D3R, respectively. SB-277011 hydrochloride displays 80- to 100-fold selectivity over other dopamine receptors with pKis of 8.0, 6.0, <5.2, and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively[1][2].
PRICE 300
DESCRIPTION SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, and orally active dopamine D3 receptor (D3R) antagonist that crosses the blood-brain barrier, with Ki values of 10.7 nM for rodent D3R and 11.2 nM for human D3R. It is 80-100 times more selective for D3 receptors than other dopamine receptors, acting on D3 receptors (pKi: 8.0), D2 receptors (pKi: 6.0), 5-HT1B receptors (pKi < 5.2), and 5-HT1D receptors (pKi: 5.9).
DESCRIPTION Potent and selective CCR3 antagonist (Tocris Bioactive Compound Library)
DESCRIPTION SB-277011 (SB-277011A) is a specific antagonist of the dopamine D3 receptor with pKi values of 8.0, 6.0, 5.0, and <5.2 for D3 receptor, D2 receptor, 5-HT1D, and 5-HT1B respectively. (TargetMol Bioactive Compound Library)
Compound Sets
10
Axon Medchem Screening Library
1920
Cayman Chemical Bioactives
11982
Concise Guide to Pharmacology 2017/18
143
Concise Guide to Pharmacology 2019/20
143
Concise Guide to Pharmacology 2021/22
143
Concise Guide to Pharmacology 2023/24
143
Guide to Pharmacology
143
MedChem Express Bioactive Compound Library
HY-10847B
TargetMol Bioactive Compound Library
T12861
Tocris Bioactive Compound Library
4207
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
438.24
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
3
cLogP
4.84
TPSA
69.02
Fraction CSP3
0.39
Chiral centers
0.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Dopamine Receptor
D3 receptor
D3 antagonist
5-HT Receptor
Pathway
Neuronal Signaling
GPCR/G protein
Neuroscience
Primary Target
D3 Receptors
MOA
Antagonist
Source data