General
Preferred name
RAUBASINE
Synonyms
Lamuran ()
Delta-Yohimbine ()
Ajmalicin ()
Ajmalicine hydrochloride ()
ajmalicine ()
P&D ID
PD050912
CAS
4373-34-6
483-04-5
Tags
available
drug
natural product
Drug indication
Circulatory disorder
Drug Status
approved
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION An extract of the Rauwolfia serpentina plant (Indian snakeroot). Structurally related to . (GtoPdb)
DESCRIPTION Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks ¦Á1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 ¦ÌM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity[1][2].
PRICE 121
DESCRIPTION Ajmalicine (Raubasine) (Raubasine) is a potent adrenolytic agent which preferentially blocks ??1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, IC50 = 72.3 ??M. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity.
DESCRIPTION Ajmalicine (Raubasine) (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, IC50 = 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity. (TargetMol Bioactive Compound Library)
Compound Sets
9
Cayman Chemical Bioactives
31213
DrugBank
DB15949
DrugMAP
DMPOD47
DrugMAP Approved Drugs
DMPOD47
Guide to Pharmacology
8746
MedChem Express Bioactive Compound Library
HY-N1919
Other bioactive compounds
TargetMol Bioactive Compound Library
T8044
ZINC Tool Compounds
ZINC000053147422
External IDs
42
Properties
(calculated by RDKit )
Molecular Weight
352.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
5
Aromatic Ring Count
2
cLogP
3.18
TPSA
54.56
Fraction CSP3
0.48
Chiral centers
4.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
α1-adrenoceptor
AChE
Adrenergic Receptor
Cholinesterase (ChE)
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Source data