General
Preferred name
MIROGABALIN
Synonyms
DS 5565 besylate ()
DS5565 ()
Tarlige ()
MIROGABALIN BESYLATE ()
Mirogabalin (DS-5565) ()
A-200-0700 ()
Mirogabalina ()
A200-0700 ()
Mirogabaline ()
Mirogabalin ()
DS-5565 ()
Mirogabalin besilate ()
P&D ID
PD050905
CAS
1138245-13-2
1138245-21-2
Tags
available
drug candidate
drug
Approved by
PMDA
First approval
2019
Drug indication
Fibromyalgia
Cancer related pain
Peripheral neuropathy
Cardiovascular disease
Drug Status
approved
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Mirogabalin besylate is a selective and orally available ligand for the voltage-gated calcium channel α2δ subunit and is being developed for the treatment of pain associated with diabetic peripheral neuropathy, fibromyalgia and post-herpetic neuralgia. (BOC Sciences Bioactive Compounds)
Compound Sets
14
BOC Sciences Bioactive Compounds
mirogabalin-besylate-cas-1138245-21-2-373157
Cayman Chemical Bioactives
22475
ChEMBL Drugs
CHEMBL3545125
CHEMBL3545257
Concise Guide to Pharmacology 2023/24
12597
8303
Drug Repurposing Hub
DrugBank
DB11825
DrugCentral
5491
DrugCentral Approved Drugs
5491
DrugMAP
DM5GIWZ
Guide to Pharmacology
12597
8303
MedChem Express Bioactive Compound Library
HY-12650
HY-108006
Natural product-based probes and drugs
Selleckchem Bioactive Compound Library
mirogabalin-ds-5565
TargetMol Bioactive Compound Library
T7216
External IDs
33
Properties
(calculated by RDKit )
Molecular Weight
209.14
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
0
cLogP
1.78
TPSA
63.32
Fraction CSP3
0.75
Chiral centers
3.0
Largest ring
5.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
??2?? calcium channels
Calcium Channel
MOA
Calcium Channel antagonist
Biosynthetic Origin
Alkaloid
Therapeutic Indication
Neuropathic Pain
Therapeutic Class
CNS & PNS
Solubility
Soluble in DMSO
Source data