General
Preferred name
EVACETRAPIB
Synonyms
Evacetrapib (LY2484595) ()
P&D ID
PD050897
CAS
1186486-62-3
Tags
available
drug candidate
Drug indication
Cardiovascular disease
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
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[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Evacetrapib is an investigational compound which inhibits cholesterylester transfer protein (CETP) .
DESCRIPTION
Evacetrapib is a cholesterylester transfer protein (CETP) inhibitor . CETP was considered as a target for prevention of dyslipidemia and resucing cardiovascular mortality, with CETP inhibitors proposed as a direct route to raise HDL.
Clinical trial results for a number of CETP inhibitors have failed to show clinical benefit. Failed candidates include evacetrapib, , torcetrapib, and dalcetrapib . (GtoPdb)
Clinical trial results for a number of CETP inhibitors have failed to show clinical benefit. Failed candidates include evacetrapib, , torcetrapib, and dalcetrapib . (GtoPdb)
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free of charge
External IDs
8
Molecular Weight
638.28
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
3
cLogP
7.1
TPSA
87.38
Fraction CSP3
0.55
Chiral centers
1.0
Largest ring
7.0
QED
0.28
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
