General
Preferred name
CIPRALISANT
Synonyms
Cipralisant (maleate) ()
GT-2331 ()
GT-2331 (maleate) ()
CIPRALISANT MALEATE ()
Cipralisant, (-)- ()
(-)-GT-2331 ()
Gt2331 ()
Perceptin ()
GT-2331 MALEATE ()
P&D ID
PD050830
CAS
213027-19-1
223420-20-0
Tags
available
drug candidate
Drug indication
Attention deficit hyperactivity disorder
Drug Status
investigational
Max Phase
2.0
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION This compound exhibits functional selectivity for the histamine H3 receptor, displaying both agonist and antagonist actions, depending on the G protein content of the cells examined . (GtoPdb)
DESCRIPTION Cipralisant (GT-2331) is an orally active, low-toxicity, potent, selective, high affinity histamine H3 receptor full antagonist in vivo, and an agonist in vitro, with a pKi of 9.9 for histamine H3 receptor and a Ki of 0.47 nM for rat histamine H3 receptor. Cipralisant has the potential for attention-deficit hyperactivity disorder research[1][2][3][4]. Cipralisant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
DESCRIPTION Cipralisant (GT-2331) (maleate) is an orally active, low-toxicity, potent, selective, high affinity histamine H3 receptor full antagonist in vivo, and an agonist in vitro, with a pKi of 9.9 for histamine H3 receptor and a Ki of 0.47 nM for rat histamine H3 receptor. Cipralisant (maleate) has the potential for attention-deficit hyperactivity disorder research[1][2][3][4]. Cipralisant (maleate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Compound Sets
5
ChEMBL Drugs
CHEMBL278462
CHEMBL2106003
DrugMAP
DMTAKNF
Guide to Pharmacology
1244
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL278462
MedChem Express Bioactive Compound Library
HY-106993
HY-106993A
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
216.16
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
3.34
TPSA
28.68
Fraction CSP3
0.64
Chiral centers
2.0
Largest ring
5.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Histamine Receptor
Pathway
GPCR/G protein
Immunology/Inflammation
Neuronal Signaling
Source data