General
Preferred name
L-748,337
Synonyms
L748337 ()
L-748337 ()
P&D ID
PD050742
CAS
244192-94-7
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Selective CCK2 antagonist (Tocris Bioactive Compound Library)
DESCRIPTION L-748,337 is a selective and competitive β3-adrenoceptor antagonist with Ki value of 4.0 nM. It can inhibit agonist-induced relaxation of smooth muscle and lipolysis in rhesus monkey adipocytes. It also inhibits cAMP accumulation in response to isoproterenol. It reduces apoptosis, iNOS expression and attenuates nitric oxide-induced cell proliferation in a melanoma cell line. (BOC Sciences Bioactive Compounds)
Compound Sets
10
BOC Sciences Bioactive Compounds
l-748-337-cas-244192-94-7-item-129524
Cayman Chemical Bioactives
19643
Concise Guide to Pharmacology 2017/18
3932
Concise Guide to Pharmacology 2019/20
3932
Concise Guide to Pharmacology 2021/22
3932
Concise Guide to Pharmacology 2023/24
3932
DrugMAP
DM7CPBU
Guide to Pharmacology
3932
MedChem Express Bioactive Compound Library
HY-103211
Tocris Bioactive Compound Library
2760
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
497.2
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
4
Rotatable Bonds
13
Ring Count
3
Aromatic Ring Count
3
cLogP
2.7
TPSA
116.76
Fraction CSP3
0.27
Chiral centers
1.0
Largest ring
6.0
QED
0.27
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Primary Target
Adrenergic ?3 Receptors
MOA
Antagonist
Pathway
GPCR/G protein
Neuronal Signaling
Target
Adrenergic Receptor
Source data