General
Preferred name
ZD-7155
Synonyms
ZD 7155 hydrochloride ()
ZD 7155(hydrochloride) ()
ZD 7155 (hydrochloride) ()
P&D ID
PD050727
CAS
146709-78-6
Tags
available
drug candidate
Drug indication
Hypertension
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
189
DESCRIPTION
ZD-7155 is an orally active antagonist of the angiotensin II type 1 receptor. It is more potent and longer-acting than the prototype AT1 antagonist, (in rats) .
ZD-7155 has been co-crystalised with a modified human AT1 receptor with PDB structure ID 4YAY . (GtoPdb)
ZD-7155 has been co-crystalised with a modified human AT1 receptor with PDB structure ID 4YAY . (GtoPdb)
DESCRIPTION
Potent mGlu5 antagonist; also positive allosteric modulator of mGlu4 receptors
(Tocris Bioactive Compound Library)
DESCRIPTION
Selective non-peptide AT1 antagonist
(Tocriscreen Total)
DESCRIPTION
ZD 7155 hydrochloride is a potent, selective and competitive antagonist for the angiotensin II type 1 (AT1) receptor. ZD 7155 hydrochloride displaces [125I]-angiotensin II binding in guinea pig adrenal gland membranes (IC50 = 3.8 nM). ZD 7155 hydrochloride exhibits a longer acting duration compared to the prototype AT1 antagonist, losartan.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
EUbOPEN Chemogenomics Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
30
Molecular Weight
438.22
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
5
Aromatic Ring Count
4
cLogP
4.53
TPSA
87.66
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.48
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Angiotensin Receptor
AGTR1
Primary Target
Angiotensin AT1 Receptors
MOA
Antagonist
angiotensin receptor antagonist
Pathway
GPCR/G protein
Endocrinology/Hormones
Recommended Cell Concentration
10 nM
Source data
