General
Preferred name
TMCB
Synonyms
PMID22115617C2c ()
compound 2c [PMID: 22115617] ()
CK2/ERK8-IN-1 ()
P&D ID
PD050716
CAS
905105-89-7
1085822-09-8
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Compound 2c is a potent inhibitor of the alpha prime (α'; gene symbol CSNK2A2) subunit of casein kinase 2 (CK2) . The compound is four times more potent at CK2α' compared to CK2α as assessed by subunit-induced inhibition of phosphorylation of a synthetic peptide substrate . (GtoPdb)
DESCRIPTION Glucosidase inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION TMCB is a dual-kinase inhibitor of both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC50 = 0.50 μM for both CK2 and ERK8). TMCB exhibits selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (Ki = 0.25, 8.65, 11.90 and 15.25 μM for CK2, PIM1, DYRK1a and HIPK2, respectively). (BOC Sciences Bioactive Compounds)
Compound Sets
8
BOC Sciences Bioactive Compounds
tmcb-cas-905105-89-7-item-129678
Cayman Chemical Bioactives
27652
CZ-OPENSCREEN Bioactive Library
DrugMAP
DMX5UKA
Guide to Pharmacology
8140
MedChem Express Bioactive Compound Library
HY-135906
Tocris Bioactive Compound Library
3675
ZINC Tool Compounds
ZINC000058638742
External IDs
14
Properties
(calculated by RDKit )
Molecular Weight
530.74
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
4.24
TPSA
58.36
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Primary Target
Casein Kinase 2
MOA
Inhibitor
Pathway
Apoptosis
Cell Cycle/DNA Damage
JAK/STAT Signaling
MAPK/ERK Pathway
Protein Tyrosine Kinase/RTK
Stem Cell/Wnt
Target
Casein kinase
DYRK
ERK
Pim
Source data