General
Preferred name
AZD-7687
Synonyms
CHEMBL2178953 ()
AZD7687 ()
P&D ID
PD050706
CAS
1166827-44-6
Tags
available
probe
drug candidate
Drug Status
investigational
Probe info
Probe type
calculated probe
Probe sources
Tool Compound Set
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION AZD7687 is a potent, selective, reversible and orally active diacylglycerol acyltransferase 1 (DGAT1) inhibitor with an IC50 of 80 nM for human DGAT1. AZD7687 can be used for type 2 diabetes mellitus and obesity research[1][2].
DESCRIPTION AZD7687 is a potent and selective inhibtor of diacylglycerol O-acyltransferase 1 (DGAT1).
This compound was in the AstraZeneca/MRC repurposing list from 2011.
PubChem CID 42636350 represents ths molecule wih no specified stereochemisrty. (GtoPdb)
Compound Sets
7
Drug Repurposing Hub
DrugBank
DB14949
Guide to Pharmacology
7827
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL2178953
MedChem Express Bioactive Compound Library
HY-15497
ReFrame library
Tool Compound Set
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
367.19
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
3.61
TPSA
106.17
Fraction CSP3
0.43
Chiral centers
0.0
Largest ring
6.0
QED
0.84
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Diacylglycerol O-acyltransferase 1
DGAT1
Acyltransferase
MOA
diacylglycerol O acyltransferase inhibitor
Pathway
Metabolic Enzyme/Protease
Source data