General
Preferred name
ML-SA1
Synonyms
Mucolipin synthetic agonist 1 ()
WAY-238328 ()
ML SA1 ()
P&D ID
PD050668
CAS
332382-54-4
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 ¦ÌM and 52.99 ¦ÌM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral[1].
PRICE 59
DESCRIPTION ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 ??M and 52.99 ??M, respectively[1].
DESCRIPTION ML-SA1 activates the ion channel activity of TRPML1 and TRPML3 in mouse, and all three human TRPML isoforms . (GtoPdb)
DESCRIPTION ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively[1]. (TargetMol Bioactive Compound Library)
DESCRIPTION nAChR agonist; displays selectivity for beta4 subunit-containing receptors (Tocris Bioactive Compound Library)
Compound Sets
12
Cayman Chemical Bioactives
29958
Concise Guide to Pharmacology 2019/20
6386
Concise Guide to Pharmacology 2021/22
6386
Concise Guide to Pharmacology 2023/24
6386
CZ-OPENSCREEN Bioactive Library
EU-OPENSCREEN Bioactive Compound Library
EOS102249
Guide to Pharmacology
6386
MedChem Express Bioactive Compound Library
HY-108462
Selleckchem Bioactive Compound Library
ml-sa1
Selleckchem Bioactive Compound Library (Provided by Pfizer)
TargetMol Bioactive Compound Library
T23004
Tocris Bioactive Compound Library
4746
External IDs
10
Properties
(calculated by RDKit )
Molecular Weight
362.16
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
2
cLogP
3.6
TPSA
57.69
Fraction CSP3
0.32
Chiral centers
1.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
TRP Channel
TRPML
Antiviral,TRP Channel
Dengue virus
Flavivirus
MOA
Activator
Pathway
Anti-infection
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data