General
Preferred name
PSB-10
Synonyms
PSB 10 hydrochloride ()
P&D ID
PD050636
CAS
591771-91-4
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Potent 5-HT2 antagonist; also 5-HT3, H1 and alpha2 antagonist; antidepressant
(Tocris Bioactive Compound Library)
DESCRIPTION
PSB 10 is a potent and highly selective antagonist for the human adenosine A3 receptor that displays > 17000-fold selectivity over other adenosine receptors (Ki values are 0.553, > 10000, > 10000 and > 10000 nM for A2B, A1, A2A and A3 receptors respectively). It produces thermal hyperalgesia in mice in vivo.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
3
BOC Sciences Bioactive Compounds
Guide to Pharmacology
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
13
Molecular Weight
397.03
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
2
cLogP
4.45
TPSA
64.59
Fraction CSP3
0.31
Chiral centers
1.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Adenosine A3 Receptors
MOA
Antagonist
Source data
