General
Preferred name
RESINIFERATOXIN
Synonyms
(+)-Resiniferatoxin ()
Neuroclastin ()
Lopain ()
MTX-71 ()
Mtx-071 ()
RTX ()
P&D ID
PD050559
CAS
57444-62-9
Tags
available
drug candidate
natural product
Drug indication
Pain
Neuropathic pain
Cancer related pain
osteoarthritis, knee
Osteoarthritis
Drug Status
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION
Investigated for use/treatment in interstitial cystitis and urinary incontinence.
DESCRIPTION
Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period[1][2].
PRICE
300
DESCRIPTION
Resiniferatoxin ((+)-Resiniferatoxin) is a highly potent synthetic TRPV1 agonist that inhibits the production of Th1 cytokines and has anti-inflammatory activity, reducing serum levels of IL-12, INF-??, IL-1??, TNF-??, NO, and PGE.
DESCRIPTION
Resiniferatoxin, an extract from resin spurge (Euphorbia resinifera), is a TRPV1 agonist.
There is some ambiguity online and in the literature as to the exact stereochemistry of resiniferatoxin. The representation shown here matches that in the PubChem and ChEMBL links above, while several tautomers and stereoisomers are also listed on PubChem, and ChEBI represents the compound with the entry CHEBI:8809. (GtoPdb)
There is some ambiguity online and in the literature as to the exact stereochemistry of resiniferatoxin. The representation shown here matches that in the PubChem and ChEMBL links above, while several tautomers and stereoisomers are also listed on PubChem, and ChEBI represents the compound with the entry CHEBI:8809. (GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
3
Compound Sets
9
ChEMBL Drugs
DrugBank
DrugMAP
MedChem Express Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
29
Molecular Weight
628.27
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
7
Aromatic Ring Count
2
cLogP
4.74
TPSA
120.75
Fraction CSP3
0.46
Chiral centers
8.0
Largest ring
7.0
QED
0.32
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Therapeutic Class
Analgesics
Target
TRP Channel
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data
