General
Preferred name
DHβE
Synonyms
Dihydro-beta-erythroidine hydrobromide ()
Dihydro-Beta-erythroidine ()
Dihydro-β-erythroidine (hydrobromide) ()
DHβE (hydrobromide) ()
Dihydro-β-erythroidine hydrobromide ()
Dihydro-¦Â-erythroidine (hydrobromide) ()
DH¦ÂE (hydrobromide) ()
P&D ID
PD050558
CAS
29734-68-7
1328-90-1
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Dihydro-¦Â-erythroidine (DH¦ÂE) hydrobromide is a potent, orally active, and competitive antagonist of neuronal nAChRs. Dihydro-¦Â-erythroidine hydrobromide shows selectivity for ¦Á4¦Â4 and ¦Á4¦Â2 nAChRs, with IC50s of 0.19 and 0.37 ¦ÌM, respectively. Antidepressant-like activities[1][2][3].
DESCRIPTION
Na+ channel blocker
(Tocris Bioactive Compound Library)
DESCRIPTION
Competitive nicotinic acetylcholine receptor antagonist.
(LOPAC library)
DESCRIPTION
The hydrobromide salt form of Dihydro-β-erythroidine, which is a competitive nAChR antagonist and has been found to show antagonizes behavioral effects of nicotine in vivo.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
BOC Sciences Bioactive Compounds
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
32
Molecular Weight
275.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
0
cLogP
1.81
TPSA
38.77
Fraction CSP3
0.69
Chiral centers
2.0
Largest ring
6.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
nAch
Primary Target
Nicotinic Receptors (Other Subtypes)
MOA
Antagonist
Nicotinic alpha4beta2 Antagonists
acetylcholine receptor antagonist
Member status
virtual
Target
CHRNA4, CHRNB2
nAChR
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data
