General
Preferred name
ISOGUVACINE
Synonyms
ISOGUVACINE HYDROCHLORIDE ()
Isoguvacine (hydrochloride) ()
Artemisinin SP ()
Isoguvacine HCl ()
P&D ID
PD050541
CAS
68547-87-7
68547-97-7
64603-90-3
Tags
natural product
drug
available
Drug indication
Malaria
Drug Status
approved
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
GABA-A receptor agonist
(LOPAC library)
DESCRIPTION
Potent NMDA antagonist; more active enantiomer of (RS)-CPP
(Tocris Bioactive Compound Library)
DESCRIPTION
Selective GABAA agonist
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
16
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
Ki Database
LOPAC library
MedChem Express Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
38
Molecular Weight
127.06
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
0
cLogP
-0.01
TPSA
49.33
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
GABA-A, GABA-C
Primary Target
GABAA Receptors
MOA
Agonist
benzodiazepine receptor agonist
Target
GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRR1, GABRR2, GABRR3
GABA Receptor
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data
