General
Preferred name
zinc protoporphyrin IX
Synonyms
ZINC(II) PROTOPORPHYRIN IX ()
P&D ID
PD050495
CAS
15442-64-5
Tags
natural product
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
ZnPP is reported as an antagonist of the estrogen receptor β . The PubChem identifier for protoporphyrin IX is CID 4971. This is a very similar structure to iron bound heme, but with the ferrous ion replaced by a zinc ion.
(GtoPdb)
DESCRIPTION
Zinc protoporphyrin IX is an endogenous metabolite formed during heme biosynthesis and a heme oxygenase inhibitor. Heme oxygenase is the enzyme producing CO, which is an activator of guanylyl cyclase and shares some chemical and biological properties of NO. Zinc protoporphyrin IX has been shown to inactivates the NOS isoforms nNOS, iNOS, and eNOS(IC50 = 0.8, 4, and 5 μM, respectively).
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
3
BOC Sciences Bioactive Compounds
DrugMatrix
Guide to Pharmacology
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Molecular Weight
624.17
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
5
Aromatic Ring Count
3
cLogP
6.76
TPSA
128.58
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
16.0
QED
0.26
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
