General
Preferred name
CGS-12066
Synonyms
CPD000468733 ()
CGS-12066A maleate ()
CGS 12066B DIMALEATE ()
CGS 12066B ()
CGS-12066B ()
P&D ID
PD050455
CAS
109028-10-6
109028-09-3
Tags
drug candidate
natural product
available
Drug indication
Anxiety disorder
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
5-HT1B Serotonin receptor agonist
(LOPAC library)
DESCRIPTION
H3 antagonist; also H4 inverse agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
CGS 12066B dimaleate is a 5-HT1B full agonist, which is 10-fold selective over 5-HT1A and 1000-fold selective over 5-HT2C receptors.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
13
Axon Medchem Screening Library
Bioprocess diversity set
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
DrugMAP
DrugMatrix
Guide to Pharmacology
Ki Database
LOPAC library
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
51
Molecular Weight
334.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
3
cLogP
3.26
TPSA
23.78
Fraction CSP3
0.35
Chiral centers
0.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
5-HT1B
Biological process
Resipration, oxidative phosphorylation, & mitochondrial targeting
Primary Target
5-HT1B Receptors
MOA
Agonist
5-HT1B Agonists
Member status
member
Target
5-HT1B agonist
Source data
