General
Preferred name
N/OFQ-(1-13)-NH2
Synonyms
Nociceptin (1-13) amide TFA ()
N/OFQ-(1-13)-NH2 ()
P&D ID
PD050414
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Synthetic analogue of N/OFQ
(GtoPdb)
DESCRIPTION
Nociceptin (1-13), amide is a potent agonist Opioid receptor-like1 (ORL1) receptor with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
3
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Molecular Weight
1380.77
Hydrogen Bond Acceptors
20
Hydrogen Bond Donors
22
Rotatable Bonds
47
Ring Count
2
Aromatic Ring Count
2
cLogP
-9.23
TPSA
639.61
Fraction CSP3
0.56
Chiral centers
11.0
Largest ring
6.0
QED
0.02
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Opioid receptor-like1 (ORL1)
Pathway
Endocrinology/Hormones
GPCR/G protein
Neuroscience
Source data
