General
Preferred name
TIOSPIRONE
Synonyms
TIOSPERONE ()
BMY-13859 hydrochloride ()
Tiaspirone hydrochloride(87691-91-6 Free base) ()
BMY 13859-1 ()
Tiospirone hydrochloride ()
Tiaspirone hydrochloride ()
BMY-13859 ()
Tiospirona ()
BMY-138591 ()
Tiospirone hcl ()
BMY-13859-1 ()
P&D ID
PD050342
CAS
87691-91-6
87691-92-7
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 532
PRICE 672
DESCRIPTION Tiospirone (BMY 13859-1 free base) is a 5-HT2 receptor antagonist and dopamine blocker that inhibits D2, 5-HT1a, 5-HT7, and sigma receptors.Tiospirone is used in the study of neurological disorders such as schizophrenia. (TargetMol Bioactive Compound Library)
DESCRIPTION Tiaspirone hydrochloride (BMY-13859 hydrochloride) exhibits antipsychotic activity. Tiaspirone hydrochloride influences the electrophysiological activity of dopaminergic neurons in the substantia nigra zona compacta (A9 DA cells) and ventral tegmental area (A10 DA cells) in the brain of the rat. (TargetMol Bioactive Compound Library)
Compound Sets
8
ChEMBL Drugs
CHEMBL35057
CHEMBL1204189
DrugMAP
DME5QDP
DrugMatrix
Guide to Pharmacology
101
Ki Database
TIOSPERONE
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
TargetMol Bioactive Compound Library
T24885
T24885L
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
440.22
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
5
Aromatic Ring Count
2
cLogP
3.91
TPSA
56.75
Fraction CSP3
0.62
Chiral centers
0.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT2
D2
5-HT1A
5-HT7
Member status
virtual
MOA
alpha1-Adrenoceptor Antagonists
Pathway
GPCR/G protein
Neuroscience
Source data