General
Preferred name
ASENAPINE
Synonyms
Asenapine maleate ()
Asenapine maleate ()
Saphris ()
Asenapine (maleate) ()
Asenapine (hydrochloride) ()
Org 5222 maleate ()
Org 5222 (hydrochloride) ()
Org 5222 ()
(±)-Asenapine ()
P&D ID
PD050340
CAS
65576-45-6
135882-95-0
1412458-61-7
85650-56-2
Tags
available
drug
Drug indication
Schizophrenia
Drug Status
approved
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Asenapine maleate is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and D2 antagonist with Ki values of 0.03-4.0 nM, 1.3nM, respectively, and an antipsychotic.
DESCRIPTION
Asenapine hydrochloride, an antipsychotic, is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and Dopamine (D2, D3, D4) receptor antagonist with Ki values of 0.03-4.0 nM for 5-HT and 1.3, 0.42, 1.1 nM for Dopamine receptor, respectively.
DESCRIPTION
Asenapine is an atypical antipsychotic. The drug is an enantiomeric mixture, and we show one enantioner here. Alternative enantiomers include CHEMBL1201756.
Marketed formulations may contain asenapine maleate (PubChem CID 6917875). (GtoPdb)
Marketed formulations may contain asenapine maleate (PubChem CID 6917875). (GtoPdb)
DESCRIPTION
Asenapine is an atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. It is a serotonin, dopamine, noradrenaline, and histamine antagonist.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
17
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
NCATS Inxight Approved Drugs
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
44
Molecular Weight
285.09
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
4.26
TPSA
12.47
Fraction CSP3
0.29
Chiral centers
2.0
Largest ring
7.0
QED
0.72
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Dopamine D2 receptor
Serotonin 2a (5-HT2a) receptor
DRD2, HRH1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A
Atypical antipsychotic
5-HT Receptor
Adrenergic Receptor
Dopamine Receptor
Histamine Receptor
5-HT Receptor,Adrenergic Receptor
MOA
serotonin receptor antagonist
Dopamine Receptor antagonist
alpha adrenergic receptor antagonist
Dopamine D1 Antagonists
Dopamine D2 Antagonists
5-HT2 Antagonists
dopamine receptor antagonist, serotonin receptor antagonist
Member status
member
Indication
schizophrenia, bipolar disorder
Pathway
GPCR/G protein
Neuronal Signaling
Immunology/Inflammation
Source data
