General
Preferred name
SR59230A
Synonyms
SR 59230A hydrochloride ()
SR59230A HCl ()
SR59230A (hydrochloride) ()
SR59230A hydrochloride ()
SR 59230A (hydrochloride) ()
P&D ID
PD050309
CAS
1135278-41-9
174689-38-4
174689-39-5
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating ¦Â3-adrenergic receptor antagonist[1] with IC50s of 40, 408, and 648 nM for ¦Â3, ¦Â1, and ¦Â2 receptors, respectively[2].
PRICE
98
DESCRIPTION
SR59230A hydrochloride (SR59230A HCl) is a blood-brain permeable, selective and highly potent ??3-adrenergic receptor antagonist that inhibits ultradian brown adipose tissue thermogenesis and interrupts associated paroxysmal brain and body heating.
DESCRIPTION
SR59230A is a potent, selective, and blood-brain barrier penetrating ¦Â3-adrenergic receptor antagonist[1] with IC50s of 40, 408, and 648 nM for ¦Â3, ¦Â1, and ¦Â2 receptors, respectively[2].
PRICE
157
DESCRIPTION
SR59230A is a potent, selective antagonist of ??3-adrenergic receptor(??3, ??1, and ??2 receptors with IC50s of 40, 408, and 648 nM , respectively).
DESCRIPTION
Potent and selective beta3 antagonist
(Tocriscreen Plus)
DESCRIPTION
Potent and selective β3 antagonist
(Tocriscreen Total)
DESCRIPTION
SR 59230A hydrochloride is a potent, selective and orally available β3 adrenoceptor antagonist (IC50 = 40, 408 and 648 nM for β3, β1 and β2 receptors, respectively). SR 59230A blocks MDMA-induced hyperthermia at low concentrations, while it blocks hyperthermia and also increases heat loss through an α1-AR antagonistic mechanism at high concentrations.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Positive allosteric modulator of GABAB receptors
(Tocris Bioactive Compound Library)
DESCRIPTION
SR59230A hydrochloride (SR59230A HCl) is a blood-brain permeable, selective and highly potent β3-adrenergic receptor antagonist that inhibits ultradian brown adipose tissue thermogenesis and interrupts associated paroxysmal brain and body heating.
(TargetMol Bioactive Compound Library)
DESCRIPTION
SR59230A is a potent, selective antagonist of β3-adrenergic receptor(β3, β1, and β2 receptors with IC50s of 40, 408, and 648 nM , respectively).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
14
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
Guide to Pharmacology
Selleckchem Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
44
Molecular Weight
325.2
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
2
cLogP
3.66
TPSA
41.49
Fraction CSP3
0.43
Chiral centers
2.0
Largest ring
6.0
QED
0.82
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Target
β3-adrenergic receptor
Adrenergic Receptor
β3-adrenoceptor
ADRB1, ADRB2, ADRB3
Primary Target
Adrenergic ?3 Receptors
MOA
Antagonist
Adrenergic Receptor antagonist
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Source data
