General
Preferred name
flupentixol
Synonyms
cis-(Z)-Flupenthixol dihydrochloride ()
Emergil ()
flupenthixol ()
cis-Flupenthixol hydrochloride ()
Flupenthixol dihydrochloride ()
1-piperazineethanol, 4-[3-[2- (trifluoromethyl)thioxanthen-9-ylidene]propyl]-, dihydrochloride ()
cis-Flupenthixol (hydrochloride) ()
Z-FLUPENTIXOL ()
P&D ID
PD050297
CAS
51529-01-2
2709-56-0
53772-82-0
2413-38-9
Tags
available
drug
Drug indication
Schizophrenia
Depression
Drug Status
approved
withdrawn
investigational
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
The approved drug flupentixol (aka flupenthixol) is the cis form. Flupenthixol is not approved for marketing by US FDA, but is available in other countries. For the structure of the trans form please see our entry for .
(GtoPdb)
DESCRIPTION
Dopamine receptor antagonist; antipsychotic
(LOPAC library)
DESCRIPTION
Flupenthixol dihydrochloride is a dopamine receptor antagonist used as an antipsychotic drug for schizophrenia treatment. Mixture of E/Z isomers (ratio: 60:40).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
cis-Flupenthixol is a typical antipsychotic, a dopamine D2 receptor antagonist, and an inverse agonist at the serotonin (5-HT) receptor subtype 5-HT2A. In vivo, cis-flupenthixol reduces cocaine-induced locomotor activity and prevents development of conditioned place preferences for the immediate effects of intravenously administered cocaine without affecting development of conditioned place aversions in rats. It is also a neuroleptic agent related structurally to thiothixene.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
15
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugMAP Approved Drugs
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
434.16
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
2
cLogP
4.6
TPSA
26.71
Fraction CSP3
0.39
Chiral centers
0.0
Largest ring
6.0
QED
0.63
Structural alerts
1
styrene_B(8)
c:1:c:c-2:c(:c:c:1)-[#6](-c:3:c(-[$([#16;X2]),$([#6;X4])]-2):c:c:[c;!H0,$(c-[#17]),$(c-[#6;X4])](:c:3))=[#6]-[#6]
PAINS Family C
Related compounds
Custom attributes
(extracted from source data)
Indication
schizophrenia, depression
Target
ADRA1A, CHRM1, DRD1, DRD2, DRD3, DRD5, HTR2A
MOA
Dopamine Receptor antagonist
Therapeutic Class
Antipsychotic Neuroleptic drug
Antipsychotic Agents
Source data
