General
Preferred name
U-50488 METHANE SULFONATE
Synonyms
(+)-U-50488 hydrochloride ()
U50,488H ()
U50488 ()
U-50488 ()
(+)-Trans-(1R,2R0-U-50488 HCl ()
NCG-C00094496-01 ()
U-50488 CHLORIDE ()
NCG-C00093883-01 ()
U-50488H ()
U-50488 (hydrochloride) ()
P&D ID
PD050289
CAS
114528-81-3
83913-06-8
67197-96-0
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Drug Status
investigational
Max Phase
Phase 1
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
(+)-U-50488 hydrochloride is the less active enantiomer of (±)-U-50488, which is an opioid receptor agonist.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
alpha partial agonist; also D2-like partial agonist and 5-HT antagonist
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
3
Compound Sets
10
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugMAP
Guide to Pharmacology
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
28
Molecular Weight
368.14
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
1
cLogP
4.4
TPSA
23.55
Fraction CSP3
0.63
Chiral centers
2.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
? Opioid Receptors
MOA
Agonist
Source data
