General
Preferred name
CARVACROL
Synonyms
Karvakrol ()
O-Thymol ()
cymophenol ()
Isopropyl-o-cresol ()
2-hydroxy-p-cymene ()
NSC-6188 ()
Isothymol ()
Dentol ()
2-p-cymenol ()
Antioxine ()
FEMA NO. 2245 ()
P&D ID
PD050213
CAS
499-75-2
95909-43-6
Tags
available
drug candidate
natural product
Drug indication
Discovery agent
Drug Status
experimental
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Carvacrol is a terpenoid compound found in oils extracted from herbal plants such as oregano and thyme.
(GtoPdb)
DESCRIPTION
Carvacrol is an orally active monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations[1][2].
PRICE
29
DESCRIPTION
Carvacrol is a monoterpenoid phenol isolated from Lamiaceae family plants, with antibiotic, antioxidant, anti-inflammatory properties. Carvacrol has significant antimicrobial potential against ESBL E. coli.
(Enamine Bioactive Compounds)
DESCRIPTION
1. Carvacrol (O-Thymol) presents anxiolytic effects. 2. 5-Isopropyl-2-methylphenol presents antinociceptive activity. 3. Carvacrol presents antidepressant effects, seems to be dependent on its interaction with the dopaminergic system, but not with the serotonergic and noradrenergic systems.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugMAP
Enamine Bioactive Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
38
Molecular Weight
150.1
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
2.82
TPSA
20.23
Fraction CSP3
0.4
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Apoptosis
Metabolism
Microbiology/virology
Neuroscience
Proteases/Proteasome
Stem Cells
Anti-infection
Metabolic Enzyme/Protease
Neuronal Signaling
Stem Cell/Wnt
Target
Bacterial
Endogenous Metabolite
Fungal
Notch
AChR
Source data
