General
Preferred name
TCS-OX2-29
Synonyms
TCS OX2 29 ()
TCS-OX 2-29 ()
P&D ID
PD050164
CAS
372523-75-6
1610882-30-8
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Positive allosteric modulator of M4 receptors (Tocris Bioactive Compound Library)
DESCRIPTION TCS OX2 29 is a potent and selective OX2 receptor antagonist (IC50 = 40 nM) displaying >250-fold selectivity for OX2 over OX1 and a range of receptors, ion channels and transporters. Orexin is a neuropeptide produced in the lateral hypothalamus (LH) regulates arousal, pain and appetite. (BOC Sciences Bioactive Compounds)
DESCRIPTION Potent and selective OX2 antagonist (Tocriscreen Plus)
Compound Sets
14
BOC Sciences Bioactive Compounds
tcs-ox2-29-cas-372523-75-6-item-410106
Cayman Chemical Bioactives
17419
Concise Guide to Pharmacology 2017/18
4038
Concise Guide to Pharmacology 2019/20
4038
Concise Guide to Pharmacology 2021/22
4038
Drug Repurposing Hub
DrugMAP
DML8RTO
Guide to Pharmacology
4038
MedChem Express Bioactive Compound Library
HY-100452
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
tcs-ox2-29
TargetMol Bioactive Compound Library
T4965
Tocris Bioactive Compound Library
3371
Tocriscreen Plus
3371
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
397.24
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
2
cLogP
3.19
TPSA
63.69
Fraction CSP3
0.48
Chiral centers
1.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Pathway
GPCR/G protein
Neuronal Signaling
Target
OX2
HCRTR2
Orexin Receptor (OX Receptor)
Primary Target
OX2 Receptors
MOA
OX Receptor
Antagonist
HCRTR2 antagonist
Orexin OX-2 Antagonists
orexin receptor antagonist
Member status
member
Source data