General
Preferred name
CCT129957
Synonyms
P&D ID
PD050139
CAS
883098-58-6
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION CCT129957 is an indole derivative and a potent phospholipase C-¦Ã (PLC-¦Ã) inhibitor with an IC50 of ~3 ¦ÌM and a GC50 of 15 ¦ÌM. CCT129957 inhibits Ca2+ release in squamous carcinoma cells at ~15 ¦ÌM[1][2].
PRICE 99
DESCRIPTION CCT129957 is a novel and potent phospholipase C-?? (PLC-??) inhibitor with an IC50 of about 3 ??M and a GC50 of 15 ??M.CCT129957 exhibits anticancer activity and inhibits Ca2+ release in squamous cells.
DESCRIPTION CCT129957 is one of the hit PLCγ2 inhibitors verified experimentally, following a virtual HTS effort . (GtoPdb)
DESCRIPTION CCT129957 is a novel and potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of about 3 μM and a GC50 of 15 μM.CCT129957 exhibits anticancer activity and inhibits Ca2+ release in squamous cells. (TargetMol Bioactive Compound Library)
Compound Sets
7
Concise Guide to Pharmacology 2017/18
8820
Concise Guide to Pharmacology 2019/20
8820
Concise Guide to Pharmacology 2021/22
8820
Concise Guide to Pharmacology 2023/24
8820
Guide to Pharmacology
8820
MedChem Express Bioactive Compound Library
HY-111208
TargetMol Bioactive Compound Library
T14903
External IDs
14
Properties
(calculated by RDKit )
Molecular Weight
309.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
3.05
TPSA
88.03
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.56
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
PLCγ
Ca(2+) receptor
Phospholipase
Pathway
Metabolic Enzyme/Protease
Membrane Transporter/Ion Channel
Metabolism
Source data