General
Preferred name
EMD-386088
Synonyms
EMD 386088 hydrochloride ()
EMD386088 ()
P&D ID
PD050124
CAS
1171123-46-8
54635-62-0
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
EMD386088 is a potent serotonin 6 receptor (5-HT6R) agonist. EMD386088 regulates the activity of ERK1/2. EMD386088 has the potential for the research of alzheimer's disease (AD) and schizophrenia[1][2][3].
DESCRIPTION
This compound was discovered as the result of a medicinal chemistry programme directed towards the design and synthesis of new tool compounds which are potent and selective 5-HT6 receptor agonists . Such a tool compound could be used to investigate the in vivo functional role of 5-HT6 receptors.
(GtoPdb)
DESCRIPTION
Selective mGlu7 agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent 5-HT6 agonist
(Tocriscreen Plus)
DESCRIPTION
Potent 5-HT6 agonist
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
BOC Sciences Bioactive Compounds
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
246.09
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
2
cLogP
3.51
TPSA
27.82
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Primary Target
5-HT6 Receptors
MOA
Agonist
serotonin receptor agonist
Target
HTR6
5-HT Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Source data
