General
Preferred name
NORCHLORCYCLIZINE
Synonyms
1-(4-Chlorobenzhydryl)piperazine ()
1-[(4-chlorophenyl)(phenyl)methyl]piperazine ()
compound C10 [PMID: 24297249] ()
P&D ID
PD050054
CAS
303-26-4
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Norchlorcyclizine (C-10) is a partially selective NPR-B inhibitor. It also is an inhibitor of human tyrosyl-DNA phosphodiesterase 1.
DESCRIPTION
Partially selective GC-B (NPR-B) antagonist that mediates a strong reduction of the maximum cGMP production and no changes of the EC50 values for CNP
(GtoPdb)
DESCRIPTION
1-(4-Chlorobenzhydryl)piperazine used in treating viral infections and cancer. It has also been found as an impurity in hydroxyzine and cetirizine.
(Enamine Bioactive Compounds)
DESCRIPTION
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473 AID2293 AID2577 AID2578 AID2587 AID2588 AID2589 AID2590 AID2592 AID2593 AID2595 AID2596 AID2597 AID2613 AID2671 AID488845]
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
9
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Enamine Bioactive Compounds
Guide to Pharmacology
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Molecular Weight
286.12
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
3.33
TPSA
15.27
Fraction CSP3
0.29
Chiral centers
1.0
Largest ring
6.0
QED
0.93
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
