General
Preferred name
ILK-IN-2
Synonyms
OSU-T315 ()
ILK-IN-1 ()
PMID21823616C22 ()
OSU-T315 analog ()
compound 22 [PMID: 21823616] ()
P&D ID
PD050009
CAS
1333146-24-9
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION ILK-IN-2 (OSU-T315 analog) is an oral PDK2 inhibitor and also an ILK inhibitor, with an IC50 of 0.6 ¦ÌM. ILK-IN-2 induces cell autophagy and apoptosis, showing anti-tumor activity. ILK-IN-2 directly abolishes AKT activation by preventing AKT from translocating to lipid rafts, triggering Caspase-dependent apoptosis in chronic lymphocytic leukemia (CLL) and extending the lifespan in TCL1 mouse models[1][2].
PRICE 131
DESCRIPTION ILK-IN-2 (OSU-T315) is a novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 ??M.
DESCRIPTION Compound 22 was a lead reported as the result of a compound screen for inhibitors of the protein kinase integrin-linked kinase (ILK) . (GtoPdb)
DESCRIPTION ILK-IN-2 (OSU-T315) is a novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 μM. (TargetMol Bioactive Compound Library)
Cell lines
6
Organisms
0
Compound Sets
7
Cayman Chemical Bioactives
36674
DrugMAP
DMXF32O
Guide to Pharmacology
8116
Mcule NIBR MoA Box Subset
MCULE-6370113035
MedChem Express Bioactive Compound Library
HY-18676B
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
T5488
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
533.24
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
4
cLogP
5.31
TPSA
62.19
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.34
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
ILK
Integrin
Ser/Thr Kinase
Caspase
PDHK
Member status
member
Pathway
Metabolic Enzyme/Protease
Cytoskeletal Signaling
Apoptosis
Autophagy
cytoskeleton
Source data